商福 教授

商福 教授，广东省视觉眼科学研究所特聘PI

中山大学中山眼科中心特聘研究员，博士生导师，北京医科大学分子生物学和生物化学系理学博士，美国TUFTS大学博士后。

1988年毕业于北京医科大学生化与分子生物学系，获博士学位。 1988-1991年在北京市眼科研究所任副研究员。 从事白内障发病机理及中药防治研究。 曾获北京市中医药管理局重点研发项目支持。  当时研发的明目清障片获北京市科技进步三等奖，获北京同仁医院内部用药资质。 1991-1993 年在美国农业部设在TUFTS大学的营养与老年健康研究中心（ Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University） 做博士后。该研究中心是世界顶级的营养学研究机构， 是美国老年人膳食指南的制定机构， 也是世界营养学专家的主要培训机构，享有“营养界黄埔军校”之美誉。博士后出站后留在该研究中心工作20余年， 主要从事热量限制（calorie restriction）、低升糖膳食（low dietary glycemic index），微量营养素补充及泛素功能对白内障和老年黄斑变性防治方面的研究  。 先后任Research Associate, Scientist II 和 Scientist I 。曾独立主持NIH，USDA及AHAF资助的多项研究课题。在国际核心期刊发表相关SCI论文70余篇，其中以第一或通讯作者发表的SCI论文30余篇。多次担任美国 NIH 科研基金和英国Wellcome基金会的评委。2013年 11月由中山大学以“百人计划”引进，在中山大学中山眼科中心任特聘研究员，国家眼科学重点实验室独立PI。博士生导师。 主持国家基金委的面上项目，国际合作重大项目，参与科技部的重大研发项目（973计划），及广东省的重大研发项目。

本所合作研究方向：晶状体发育和疾病的分子机理和再生调控。

学术兼职：

2000.2至今：葡萄牙COIMBRA大学眼科中心顾问

2007，2009， 2010，2011, 2012 年 美国 NIH 科研基金特约评委。

获得奖励：

1991 北京市科技进步三等奖

1992 北京市优秀生物化学研究二等奖

科研成果：发表SCI文章74篇，受邀参编4本专著。

部分代表性文章：

1. Jahngen‑Hodge, J., Taylor, A., Shang, F., Huang, L.L. and Mura, C. (1994).  Oxidative stress to lens crystallins. Methods in Enzymology, 233, 512‑522.

2. Shang, F. and Taylor, A. (1995)  Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells.  Biochem. J. 307,  297‑ 303.

3. Shang, F., Gong, X. and Taylor, A. (1997) Activity of ubiquitin dependent pathway in response to oxidative stress: Ubiquitin activating enzyme (E1) is  transiently upregulated. J. Biol.Chem.

4. Smith, D., Shang, F*., Nowell, T. R., Asmundsson, G., Perrone, G., Dallal, G., Scott, L., Kelliher, M., Gindelsky, B., and Taylor, A. (1999) Decreasing ascorbate intake does not affect the levels of glutathione, tocopherol or retinol in the ascorbate-requiring osteogenic disorder shionogi rats  J. Nutr. 129, 1229-1232.

5. Shang, F*., Gong, X., Meydani, M., Smith, D., Perrone, G., Scott, L., Blumberg, J.B. and Taylor A. (2002) Vitamin C prevents hypobaric oxygen-induced growth retatation and lipid peroxidation and  attenuates the oxidation-induced up-regulation of glutathione in guinea pigs.  J. Nutr. Biochem. 13, 307‑313.

6. Shang, F*., Lu, M., Dudek, E., Reddan, J.,and Tayor, A. (2003) Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2.  Free Radic. Biol. Med. 34, 521-530.

7. Guo, W., Shang, F.  Liu, Q., Urim, L., West-Mays, J., and Taylor, A.           (2004) Differential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiation. Invest Ophthalmol Vis Sci. 45:1194-1201.

8. Marques, C., Pereira, P., Taylor, A., Liang, J,N,, Reddy, V.N., Szweda, L.I. and Shang, F*. (2004) Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. FASEB J. 18:1424-1426.

9. Shang, F*.,  Deng, G., Liu, Q., Guo, W., Haas, A.L., Crosas, B., Finley, D.and Taylor, A. (2005) Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J. Biol. Chem. 280:20365-20374.

10. Girão, H. Pereira, H., Taylor, and Shang, F*. (2005) Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation.  Invest. Ophthal.Vis. Res.  46: 1386-1392.

11. Dudek, E.J. Shang, F., Valverde, P., Liu, Q., Hobbs, M., Taylor, A (2005). Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases. FASEB J. 19:1707-9.

12. Marques, C., Guo, W., Pereira, P., Taylor, A., Patterson, C., Evans, PC., and Shang, F* (2006)   The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. FASEB J. 20:741-3

13. Liu, Y., Zhang, X,, Luo, L. Wu, M., Zeng, R., Cheng, G., Hu, B., Liu, B., Liang, JJ., Shang, F* (2006). A novel alphaB-crystallin mutation associated with autosomal dominant congenital lamellar cataract.  Invest Ophthalmol Vis Sci.; 47:1069-75.

14. Zetterberg, M. Zhang, X., Taylor, A., Liu, B., Liang, J.J. and Shang, F*. (2006)  Glutathiolation enhances the degradation of gammaC-crystallin in lens and reticulocyte lysates, partially via the ubiquitin-proteasome pathway. Invest. Ophthalmol. Vis. Sci. 47:3467-73

15. Fernandes AF, Zhou J, Zhang X, Bian Q, Sparrow J, Taylor A, Pereira P and Shang F* (2008). Oxidative inactivation of the proteasome in RPE: A potential link between oxidative stress and upregulation of IL-8. J. Biol. Chem.  283:20745-53

16. Zhang X, Zhou J, Fernandes AF, Sparrow J, Pereira P, Taylor A and Shang F*.(2008) The The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells. Invest Ophthalmol Vis Sci.;49:3622-30

17. Wu M, Bian Q, Liu Y, Fernandes AF, Taylor A, Pereira P, and Shang F* (2009).  Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome. Free Radic Biol Med ; 46:62-9.

18. Fernandes AF, Bian Q, Jiang JK, Thomas CJ, Taylor A, Pereira P, Shang F* (2009) Proteasome inactivation promotes p38 MAPK-dependent PI3K activation and increases IL-8 production in retinal pigment epithelial cells. Mol Biol Cell. 20: 3690–9.

19. Shang, F*. and Allen Taylor (2011) Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radic Biol Med 51:5-16

20. Wu M,  Zhang X, Bian Q,  Taylor A,  Liang JJ, Ding L, Horwitz J,  Shang F*. （2012）Oligomerization with wt αA- and αB-crystallins reduces proteasome-mediated degradation of C-terminally truncated αA-crystallin. Invest Ophthalmol Vis Sci. 53(6):2541-50

21. Bian Q, Qin T, Ren Z, Wu D, Shang F* (2012) Lutein or zeaxanthin supplementation suppresses inflammatory responses in retinal pigment epithelial cells and macrophages. Adv Exp Med Biol. 723:43-50.

22. Liu Z, Taylor A, Liu, Y. Gong X, Shang F*. (2012) Enhancement of Ubiquitin Conjugation Activity Reduces Intracellular Aggregation of V76D mutant γD-crystallin. Invest Ophthalmol Vis Sci. 53: 6655-65

23. Bian Q, Gao S, Zhou J, Qin J, Taylor A, Johnson1JJ, Tang G, Sparrow JR Gierhart D, and Shang F* (2012) Lutein and zeaxanthin supplementation reduces photo-oxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radic Biol Med, 53(6):1298-307

24. Shang F*, Wilmarth P, Chang M, Liu K,  David L, Caceres M, Wawrousek E and  Taylor A (2014)  Newborn mouse lens proteome and its alteration by lysine 6 mutant ubiquitin.. J Proteome Res  13:1177-89

25. Liu Z, Qin T, Zhou J, Taylor A, Sparrow JR, Shang F*. (2014) Impairment of the Ubiquitin-Proteasome Pathway in RPE Alters the Expression of Inflammation Related Genes.  Adv Exp Med Biol.  801:237-50

26. Zhang X, Taylor A, Liu Y, Shang F. (2017) Glutathiolation triggers proteins for degradation by the ubiquitin- proteasome pathway. Curr Mol Med. 17:258-269

27. Zhou Y, Zhou L, Zhou K, Zhang J, Shang F*, Zhang X (2019) Celastrol Protects RPE Cells from Oxidative Stress-Induced Cell Death via Activation of Nrf2 Signaling.  Curr Mol Med. 19:172-182

She C, Shang F, Cui M, Yang X, Liu N.(2021) Association between dietary antioxidants and risk for diabetic retinopathy in a Chinese population. Eye (Lond). 35:1977-1984