皮荣标 教授

皮荣标，广东省视觉眼科学研究所特聘PI

中山大学医学院药理系教授、医学博士、博士生导师。

本所合作研究方向：眼科药物开发

 2002年于中山大学医学院获得药理学博士学位，香港科技大学（2002）、新西兰奥克兰大学（2005）和美国耶鲁大学医学院（2009）开展博士后。主要从事神经药理学和分子神经生物学研究。担任多个基金评审专家（包括国家自然科学基金面上项目、广东省自然科学基金、广东省科技计划和广州市科技局科技计划）及广东省食品药品管理局药品注册审评专家。

学术任职：

1、 中山大学学报（医学版）、J Pharmaceutics、Frontier Med Chem 和药学研究的编委

2、 广东省药理学会理事、广东省药理学神经精神药理学专业委员会常务理事

3、 Neuroscience、J Med Chem、Neuroscientists、J Pineal Res、Apoptosis、Eur J Med Chem、BMC Lett及J Alzheimer Dis特邀审稿人

获得荣誉：获得教育科技进步二等奖1项。

科研成果：

主持国家自然科学基金与香港研究资助局联合项目、国家自然科学基金(3项)、国家自然科学基金国际合作交流项目、科技部中意联委科技合作项目、广东省科技计划、广东省自然科学基金项目和深港澳科技计划A类项目；参加多项包括科技部重大新药创制专项在内的国家级、省级研究项目。近年在Mol Neurobiol、J Biol Chem、J Neurochem、Br J Pharmacol、PLoS ONE、EJMC、Toxicol Lett、Brain Res和Neurosci Lett等杂志发表论文近100余篇。论文他引次数3600余次，H指数38。申请授权国家发明专利12项（中国专利11项，美国专利1项）。

近5年代表部分文章：

1.        Zhu, Z., Lu, J., Wang, S., Peng, W., Yang, Y., Chen, C., Zhou, X., Yang, X., Xin, W., Chen, X., Pi, J., Yin, W., Yao, L., & Pi, R（皮荣标）. (2022). Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway. Aging Cell, 21(4), e13587.

2.        Yang, Y., Tu, Y., Lu, J., Chen, Q., Zhu, Z., Peng, W., Zhu, W., Wen, S., Zhang, J., Yin, W., & Pi, R（皮荣标）. (2022). PT109, a novel multi-kinase inhibitor suppresses glioblastoma multiforme through cell reprogramming: Involvement of PTBP1/PKM1/2 pathway. European Journal of Pharmacology, 920, 174837。

3.        Chen C, Hou J, Lu J, Zhu Z, Yang Y, Peng W, Pi, R（皮荣标）. A novel simple traumatic brain injury mouse model. Chin Neurosurg J. 2022 Apr 1;8(1):8.

4.        Peng W, Ouyang Y, Wang S, Hou J, Zhu Z, Yang Y, Zhou R, Pi, R（皮荣标）. L-F001, a Multifunctional Fasudil-Lipoic Acid Dimer Prevents RSL3-Induced Ferroptosis via Maintaining Iron Homeostasis and Inhibiting JNK in HT22 Cells. Front Cell Neurosci. 2022 Mar 31;16:774297.

5.        Xia Y, Wu Q, Mak S, Liu EYL, Zheng BZY, Dong TTX, Pi, R（皮荣标）, Tsim KWK. Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells. FASEB J. 2022 Mar;36(3):e22189.

6.        Chen, C., Lu, J., Peng, W., Mak, M. S., Yang, Y., Zhu, Z., Wang, S., Hou, J., Zhou, X., Xin, W., Hu, Y., Tsim, K. W. K., Han, Y., Liu, Q., & Pi, R（皮荣标）. (2022). Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological Research, 175, 106003.

7.        Peng, W., Zhu, Z., Yang, Y., Hou, J., Lu, J., Chen, C., Liu, F., & Pi, R（皮荣标）. (2021). N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells. Brain Research Bulletin, 174, 250–259.

8.        Mak, S., Li, W., Fu, H., Luo, J., Cui, W., Hu, S., Pang, Y., Carlier, P. R., Tsim, K. W., Pi, R（皮荣标）, & Han, Y. (2021). Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget. Journal of Neurochemistry, 10.1111/jnc.15379.

9.        Chen, C., Chen, Y., Lu, J., Chen, Z., Wang, C., & Pi, R（皮荣标）. (2021). Acrolein-conjugated proteomics in brains of adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice. Toxicology Letters, 344, 11–17.

10.    Cheng, L., Chen, Q., Pi, R（皮荣标）, & Chen, J. (2021). A research update on the therapeutic potential of rhein and its derivatives. European Journal of Pharmacology, 899, 173908.

11.    Kong, X., Chen, Z., Xia, Y., Liu, E., Ren, H., Wang, C., Hu, W., Dong, T., Pi, R（皮荣标）, & Tsim, K. (2020). Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage. Evidence Based Complementary and Alternative Medicine, 2020, 4181696.

12.    Wu, Q., Bai, P., Xia, Y., Lai, Q., Guo, M., Dai, K., Zheng, Z., Ling, C., Dong, T., Pi, R（皮荣标）, & Tsim, K. (2020). Solar light induces expression of acetylcholinesterase in skin keratinocytes: Signalling mediated by activator protein 1 transcription factor. Neurochemistry International, 141, 104861.

13.    Chen, Q., Tu, Y., Mak, S., Chen, J., Lu, J., Chen, C., Yang, X., Wang, S., Wen, S., Ma, S., Li, M., Han, Y., Wah-Keung Tism, K., & Pi, R（皮荣标）. (2020). Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo. European Journal of Pharmacology, 173361. (IF:4.432)

14.    Lu, J., Chen, C., Deng, X., Mak, M. S., Zhu, Z., He, X., Liang, J., Maddili, S. K., Tsim, K., Han, Y., & Pi, R（皮荣标）. (2020). Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram-Tranilast Hybrids as Potential Treatment for Traumatic Brain Injury. ACS Chemical Neuroscience, 11(15), 2348–2360.

15.    Chen, J., Luo, B., Wen, S., & Pi, R（皮荣标）. (2020). Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug. Investigational New Drugs, 38(3), 755–764.

16.    Jiang, Y., Jin, M., Chen, J., Yan, J., Liu, P., Yao, M., Cai, W., & Pi, R（皮荣标）. (2020). Discovery of a novel niacin-lipoic acid dimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects. European Journal of Pharmacology, 868, 172871.

17.    Zhang, L., Chen, C., Mak, M. S., Lu, J., Wu, Z., Chen, Q., Han, Y., Li, Y., & Pi, R（皮荣标）. (2020). Advance of sporadic Alzheimer's disease animal models. Medicinal Research Reviews, 40(1), 431–458.

18.    Wang, R., Zhang, L., Liao, R., Li, Q., Pi, R（皮荣标）, & Yang, X. (2019). N2L, a novel lipoic acid-niacin dimer protects HT22 cells against β-amyloid peptide-induced damage through attenuating apoptosis. Metabolic Brain Disease, 34(6), 1761–1770.

19.    Sestito, S., Wang, S., Chen, Q., Lu, J., Bertini, S., Pomelli, C., Chiellini, G., He, X., Pi, R（皮荣标）, & Rapposelli, S. (2019). Multi-targeted ChEI-copper chelating molecules as neuroprotective agents. European Journal of Medicinal Chemistry, 174, 216–225.

20.    Zhang, X., He, X., Chen, Q., Lu, J., Rapposelli, S., & Pi, R（皮荣标）. (2018). A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease. Bioorganic & Medicinal Chemistry, 26(3), 543–550.

Feng, X., Lu, J., He, Z., Wang, Y., Qi, F., Pi, R（皮荣标）, & Zhang, G. (2018). Mycobacterium smegmatis Induces Neurite Outgrowth and Differentiation in an Autophagy-Independent Manner in PC12 and C17.2 Cells. Frontiers in Cellular and Infection Microbiology, 8, 201.